INVESTIGATING THE ROLE OF C-JUN N-TERMINAL KINASES IN THE PROLIFERATION OF WERNER SYNDROME FIBROBLASTS USING DIAMINOPYRIDINE INHIBITORS

Investigating the role of c-Jun N-terminal kinases in the proliferation of Werner syndrome fibroblasts using diaminopyridine inhibitors

Abstract Fibroblasts derived from the progeroid Werner syndrome show reduced replicative lifespan and a "stressed" morphology, both alleviated using the MAP kinase inhibitor SB203580.However, interpretation of these data is problematical because although SB203580 has the stress-activated kinases p38 and JNK1/2 as its preferred targets, it does show

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Predicting falls in older adults: an umbrella review of instruments assessing gait, balance, and functional mobility

Abstract Background To review the validated instruments that assess gait, balance, and functional mobility to predict falls in older adults first-aid across different settings.Methods Umbrella review of narrative- and systematic reviews with or without meta-analyses of all study types.Reviews that focused on older adults in any settings and include

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